Recent studies published in journals such as Frontiers In Integrative Neuroscience or the Journal of Neurochemistry suggest that studies on the medicinal use of cannabis is a therapeutic challenge in many fields where neurosciences cannot be left aside. For neurology the use of Cannabis derivatives such as TCH or CBD in the treatment of neurodegenerative diseases such as Alzheimer's is a unique opportunity.
The common treatments for neuropathological conditions do not currently offer options other than the treatment of some of the symptoms that accompany these diseases that attack the functioning of the brain, and some authors even report an increase in mortality in patients with dementia who were suggested to use antipsychotics, anxiolytics and antidepressants. Contrary to this, cannabis treatments appear to be more promising, among other reasons because they produce fewer side effects, and cannabis treatments may provide effective results so far little known.
The symptoms associated with neurological conditions such as Parkinson's disease, Alzheimer's disease, chronic traumatic encephalopathy, among others, are not treatable or reversible, however, the incorporation of phytocannabinoids to medical treatment and prevention of these, may enhance the effect of other treatments, especially in early stages or when there is a risk of one of these diseases. Medical treatments based on cannabis appear as a new therapeutic approach capable of combating some of the factors, such as inflammation, responsible for the progressive nature of neurodegeneration.
Some studies have reported that cannabidiol (CBD) and Δ9-THC (tetrahydrocannabinol, THC) have anxiolytic, antidepressant and antipsychotic properties. These cannabis derivatives have also shown important neuroprotective qualities, especially when combined with other natural products such as melatonin and curcumin. Natural extracts have been shown to have antioxidant properties in all methods used for their study. These properties have an effect on some of the causes of neuron loss, which underlies the subsequent decline in cognitive, motor, behavioral, and emotional functions seen in patients with these diagnoses. Therefore, the use of cannabis compounds may represent a promising option with the possibility of therapeutic use for neurodegenerative diseases such as Alzheimer's disease.